Cardiologist Explains Why Vitamin B12 Deficiency Causes Fatigue and How to Fix It

Friday - 27/06/2025 18:25
Persistent fatigue could signal a vitamin B12 deficiency, a concern affecting nearly half of the Indian population. Cardiologist Dr. Alok Chopra highlights B12's crucial role in energy production, DNA synthesis, and nervous system function. Found in fish, poultry, and fortified foods, B12 deficiency can lead to fatigue, pale skin, and neurological issues. While supplements and fortified foods can help, Dr.

Feeling exhausted all the time isn't normal. If you're experiencing persistent fatigue, even after adequate rest, it could be a sign of an underlying issue. Fatigue can be a key indicator of a vitamin B12 deficiency. This vital nutrient plays a crucial role in DNA synthesis, energy production, and the proper function of the central nervous system.

A selection of foods rich in Vitamin B12, like fish and eggs.

According to a 2019 study, approximately 47% of the Indian population suffers from a vitamin B12 deficiency. Dr. Alok Chopra, a renowned cardiologist and functional medicine expert, sheds light on the critical role of vitamin B12, its dietary sources, and the potential health risks associated with a deficiency, particularly among vegetarians.

What is Vitamin B12?

Vitamin B12 is a water-soluble nutrient essential for numerous bodily functions. As Dr. Chopra emphasizes, "It is essential for metabolism, digestion, and overall health." It is naturally found in certain foods and is also available as a dietary supplement or prescription medication.

Sources of Vitamin B12

Close-up shot of Vitamin B12 supplement pills.

Vitamin B12 is naturally present in animal-derived foods, including fish, poultry, eggs, and milk. However, it is largely absent in plant-based foods unless they are fortified. Dr. Chopra notes, "Vegetarians always have a problem with not having enough B12."

While plant-based foods generally lack B12, fortified options such as nutritional yeast and certain cereals can provide reliable sources. Dr. Chopra suggests that vegetarians consider taking supplements or consuming B12-fortified products to meet their daily requirements.

Key Functions of Vitamin B12

Vitamin B12 is vital for a wide range of bodily processes:

  • Red Blood Cell Production: Plays a pivotal role in producing healthy red blood cells and preventing megaloblastic anemia.
  • DNA Synthesis: Aids in the replication and maintenance of DNA within cells.
  • Nervous System Health: Maintains the health of nerve cells and supports the proper functioning of the nervous system.
  • Energy Production: Converts carbohydrates into glucose, providing energy for the body.
  • Brain Health: Boosts memory, focus, and overall cognitive function, potentially reducing the risk of neurodegenerative diseases.
  • Heart Health: Helps regulate homocysteine levels in the blood, reducing the risk of cardiovascular disease.
  • Overall Well-being: Contributes to mood regulation, bone health, and the health of skin, hair, and nails, while also supporting the immune system.
A person looking thoughtfully at a handful of healthy foods.

Signs of Vitamin B12 Deficiency

Despite its critical role, vitamin B12 deficiency is common. Some common symptoms include:

  • Fatigue
  • Pale or yellow skin
  • Headaches
  • Depressive symptoms
  • Gastrointestinal issues
  • Difficulty focusing
  • Glossitis and mouth ulcers
  • Weight loss
  • General feeling of unwellness

Dr. Chopra advises, "Deficiency can be cured by adequate nutrition, intramuscular injections, or even oral B12 therapy."

However, he also cautions against excessive intake of vitamin B12, noting that "Overuse can cause diarrhea, itching, rashes, headache, dizziness, nausea, and heart failure. Patients with optic neuropathy, polycythemia, gout, iron, folate deficiency, and when there are low potassium levels, you must consult a doctor."

Considerations When Taking Vitamin B12 Supplements

Dr. Chopra recommends avoiding combining vitamin B12 supplements with vitamin D. He explains, "Vitamin B12 and D should not be taken together as vitamin D is fat soluble and is absorbed better with food, and B12 is water soluble and taken on an empty stomach. Same for vitamin C."

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